GRK2 (C13.28) Aptamer Details

ID# 7698

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Structure

Chemistry

RNA

Target

G protein-coupled receptor kinase 2

Sequence (3-char table code)

G A C U/T

5'-rGprGprCprAprGprAprCprCprAprUprAprCprGprGprGprAprGprAprGprAprAprAprCprUprUprGprCprCp-3'

Molecular Weight: 9062.59

Extinction Coefficient: 282300

Binding Conditions / Buffer

Binding Buffer 20 mM Tris (pH 7.0), 50 mM NaCl, 5 mM MgCl2,2 mM DTT, and 0.1% Lubrol (without nonspecific RNA)

Binding Temp:

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Tesmer et al., Molecular Mechanism for Inhibition of G Protein-Coupled Receptor Kinase 2 by a Selective RNA Aptamer, Structure (2012), doi:10.1016/j.str.2012.05.002

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