GPC3 Targeting aptamer 1 Aptamer Details

ID# 9924

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Structure

Chemistry

DNA

Target

GPC3-positive EXOs from both cultured cells and human serum

Sequence (3-char table code)

G A C U/T

5'-dGpdTpdGpdApdCpdGpdCpdTpdCpdCpdTpdApdApdCpdGpdCpdTpdGpdApdCpdCpdCpdTpdTpdApdTpdCpdGpdApdGpdCpdCpdCpdCpdTpdCpdTpdGpdCpdGpdApdApdGpdCpdTpdApdApdCpdTpdTpdTpdGpdCpdTpdTpdCpdCpdTpdGpdTpdCpdCpdGpdTpdCpdCpdGpdApdApdCpdCpdApdApdTpdCp-3'

Molecular Weight: 22808.8 g/mole

Extinction Coefficient: 673000

Binding Conditions / Buffer

The DREAMbot platform was deployed for the incubation of the aptamer library to the cell cultures, sample separation and purification, aptamer elution.

Binding Temp: Room temperature °C

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Binyao Liu, Yaning Liu, Lei Qiu, Tian Gao, Na Sun, Yecheng Li, Renjun Pei, Haihang Ye, and Tingrui Pan ACS Nano 2026 20 (7), 5476-5488 DOI: 10.1021/acsnano.5c14524

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