Glucan-Binding Protein C (GbpC) A96 Aptamer Details

ID# 8820

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Structure

Chemistry

DNA

Target

S. mutans Glucan-Binding Protein C

Sequence (3-char table code)

G A C U/T

dApdGpdApdTpdApdCpdCpdApdApdTpdApdCpdGpdCpdTpdGpdCpdCpdCpdCpdGpdCpdCpdGpdGpdTpdCpdCpdCpdGpdApdGpdCpdTpdApdCpdApdApdCpdApdCpdTpdTpdTpdApdCpdGpdCpdCpdCpdCpdCpdCpdTpdCpdCpdCpdCpdGpdCpdCpdApdCpdTpdGpdGpdTpdApdApdCpdGpdApdCpdApdTpdCp

Molecular Weight: 23024.9 g/mole

Extinction Coefficient: 690100

Binding Conditions / Buffer

Artificial Saliva Buffer (pH 7.0): 15.06 mM NaCl, 1.54 mM KH2PO4, 2.46 mM K2HPO4, 13.95 mM KCl, 1.96 KSCN, 1.01 CaClH2O, 0.18 mM Cl2H14MgO7, 2.06 mM NH4Cl, 5.00 mM NaHCO3, 2.00 mM Urea, 1.17 mM ProClin(TM) 300 (preservative)

Binding Temp: 25°C

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Selection of streptococcal glucan-binding protein C specific DNA aptamers to inhibit biofilm formation Akos Harkai, Yoon Kee Beck, Anna Tory, Tamas Meszaros bioRxiv 2024.08.23.608024; doi: https://doi.org/10.1101/2024.08.23.608024

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