G-NB3 Aptamer Details
ID# 8113
Structure
Chemistry
DNA
Target
Activated Protein C
Category
Protein
Affinity (Kd)
0.17 nM
Length
82
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dGpdApdTpdTpdGpdTpdTpdApdCpdTpdGpdTpdCpdApdCpdGpdApdGpdGpdApdTpdTpdGpdGpdGpdGpdGpdTpdTpdGpdGpdGpdTpdGpdGpdApdTpdApdGpdGpdCpdTpdGpdGpdCpdGpdTpdCpdGpdGpdGpdGpdCpdApdGpdGpdTpdCpdApdGpdTpdApdTpdApdGpdCpdApdCpdApdTpdTpdApdGpdTpdTpdCpdApdGpdApdTpdApdCp-3'
Molecular Weight: 25630.6
Extinction Coefficient: 807400
Binding Conditions / Buffer
1X PBS
Binding Temp: 22°C
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Hamedani, N. S., Müller, J., Tolle, F., Rühl, H., Pezeshkpoor, B., Liphardt, K., … Pötzsch, B. (2020). Selective Modulation of the Protease Activated Protein C Using Exosite Inhibiting Aptamers. Nucleic Acid Therapeutics. doi:10.1089/nat.2020.0844
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