G-3 aptamer against CCR5 (HIV) Aptamer Details

ID# 8990

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Structure

Chemistry

RNA

Target

CCR5

Sequence (3-char table code)

G A C U/T

5'-rUprAprAprUprAprCprGprAprCprUprCprAprCprUprAprUprAprGprGprGprAprGprGprAprCprGprAprUprGprCprGprGprGprCprCprUprUprCprGprUprUprUprGprUprUprUprCprGprUprCprCprAprUprCprGprGprGprCprGprAprGprUprCprGprUprCprUprGp-3'

Molecular Weight: 21838 g/mole

Extinction Coefficient: 664000

Binding Conditions / Buffer

37°C for 10 min in DPBS (pH 7.0–7.4) and Ca2+ and Mg2+ (1 mM CaCl2, 2.7 mM KCl, 1.47 mM KH2PO4, 1 mM MgCl2, 136.9 mM NaCl, 2.13 mM Na2HPO4) with yeast tRNA at 100 ug/mL).

Binding Temp: 37°C

Refolding Protocol

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Zhou J, Satheesan S, Li H, Weinberg MS, Morris KV, Burnett JC, Rossi JJ. Cell-specific RNA aptamer against human CCR5 specifically targets HIV-1 susceptible cells and inhibits HIV-1 infectivity. Chem Biol. 2015 Mar 19;22(3):379-90. doi: 10.1016/j.chembiol.2015.01.005. Epub 2015 Mar 5. PMID: 25754473; PMCID: PMC4369413.

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