FLT3 (FMS-like Tyrosine Kinase-1) targeting aptamers Aptamer Details
ID# 9945
Structure
Chemistry
DNA
Target
FLT3 (fms-like tyrosine kinase-1 )
Category
Protein
Affinity (Kd)
0.423 ± 0.205 (For humans, reduced affinity observed for pigs and dogs) nM
Length
79
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dCpdTpdGpdApdCpdCpdCpdTpdGpdCpdGpdCpdCpdGpdCpdCpdGpdApdApdGpdGpdTpdTpdGpdApdGpdGpdGpdGpdApdCpdGpdGpdGpdTpdCpdApdGpdCpdGpdCpdGpdTpdApdGpdCpdGp-3'
Molecular Weight: 24288.6 g/mole
Extinction Coefficient: 714200
Binding Conditions / Buffer
The selection was conducted in 1X D-PBS-T buffer (1X D-PBS + 0.05% Tween 20).
Binding Temp: 25°C
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Owari, K., Piao, H., Hori, M. et al. Selective removal of soluble FLT-1 using a high-affinity DNA aptamer for potential apheresis treatment of preeclampsia. Sci Rep (2026). https://doi.org/10.1038/s41598-026-50826-2
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