F5R1 Aptamer Details
ID# 8218
Structure
Chemistry
DNA
Target
alpha-synuclein
Category
Protein
Affinity (Kd)
2.40 nM
Length
58
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dApdTpdCpdGpdApdGpdTpdGpdTpdGpdTpdApdCpdGpdGpdGpdGpdTpdCpdCpdGpdGpdTpdApdGpdGpdGpdTpdGpdGpdCpdGpdApdGpdGpdTpdCpdTpdTpdCpdCpdTpdGpdTpdCpdGpdTpdApdGpdCpdApdGpdGpdApdTpdCpdCpdAp-3'
Molecular Weight: 18136.69
Extinction Coefficient:
Binding Conditions / Buffer
10 mM Tris-HCI, 1 mM EDTA, 2 M NaCI, pH 7.5
Binding Temp: 25°C
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Yuan Zheng, Jing Qu, Fenqin Xue, Yan Zheng, Bo Yang, Yongchang Chang, Hui Yang, Jianliang Zhang, Novel DNA Aptamers for Parkinson’s Disease Treatment Inhibit α-Synuclein Aggregation and Facilitate its Degradation, Molecular Therapy - Nucleic Acids, Volume 11, 2018, Pages 228-242, ISSN 2162-2531
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