Ethanolamine (14.3) Aptamer Details

ID# 7456

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Structure

Chemistry

DNA

Target

Ethanolamine

Sequence (3-char table code)

G A C U/T

5'-dApdTpdApdCpdCpdApdGpdCpdTpdTpdApdTpdTpdCpdApdApdTpdTpdTpdGpdApdGpdGpdCpdGpdGpdGpdTpdGpdGpdGpdTpdGpdGpdGpdTpdTpdGpdApdApdTpdApdTpdGpdCpdTpdGpdApdTpdTpdApdCpdCpdCpdCpdApdTpdCpdGpdGpdApdGpdApdApdCpdGpdTpdTpdApdApdGpdGpdCpdGpdCpdTpdTpdCpdApdGpdApdTpdApdGpdTpdApdApdGpdTpdGpdCpdApdApdTpdCpdTp-3'

Molecular Weight: 29786.42

Extinction Coefficient: 940500

Binding Conditions / Buffer

Binding Buffer (100 mM NaCl, 20 mM Tris/HCl (pH 7.6), 2 mM MgCl2, 5 mM KCl, 1 mM CaCl2, 0.02% Tween 20).

Binding Temp: 21°C

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Mann, Doerthe, et al. "In vitro selection of DNA aptamers binding ethanolamine." Biochemical and Biophysical Research Communication, 338 (2005): 1928-1934. Tradmarked in patent, "New DNA aptamers specific for compunds that contain the ethylamino group, useful for diagnosis, prevention and treatment of ethanolaminosis, schizophrenia and neurodegeneration (Original document: DE 102005052275 (B4))"

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