Estrogen Aptamer (AptER-1) Aptamer Details

ID# 7879

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Structure

Chemistry

RNA

Target

Apo-estrogen receptor alpha

Sequence (3-char table code)

G A C U/T

dGpdGpdGpdCpdApdGpdApdCpdGpdCpdApdCpdCpdGpdCpdGpdApdApdCpdApdApdApdApdCpdGpdCpdApdApdGpdApdCpdApdGpdApdGpdTpdGpdCpdCpdGpdApdCpdApdApdGpdApdGpdCpdApdCpdTpdApdCpdApdApdGpdCpdTpdTpdCpdTpdGpdCpdCpdCp

Molecular Weight: 20019.01

Extinction Coefficient: 635300

Binding Conditions / Buffer

12 mM HEPES/pH 7.6, 150 mM NaCl, and 10 mM MgCl2

Binding Temp: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Xu, D., Chatakonda, V., Kourtidis, A., Conklin, D., and Shi, H. "In Search of Novel Drug Target Sites on Estrogen Receptors Using RNA Aptamers." Nucleic acid therapeutics 24.3 (2014): 227-38.

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