E22P-AbD43 Aptamer Details
ID# 9547
Structure
Chemistry
RNA
Target
E22P–Ab42
Category
Peptide
Affinity (Kd)
50 ± 5 nM
Length
77
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-rGprGprGprAprCprGprAprAprGprAprCprCprAprAprCprUprGprAprAprCprUprUprUprGprUprGprGprUprGprGprCprGprGprCprUprAprCprUprCprGprUprGprUprUprCprUprUprUprUprGprAprCprUprUprUprGprUprCprCprGprUprGprCprUprGprCprCprAprCprCprUprUprAprCprUprUprCp-3'
Molecular Weight: 23318.6 g/mole
Extinction Coefficient: 667500
Binding Conditions / Buffer
37°C
Binding Temp: The RNA pool or the aptamer was denatured at 90 °C for 10 min and renatured rapidly on ice for 10 min for refolding before use in the following studies.
Refolding Protocol
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Murakami K, Obata Y, Sekikawa A, Ueda H, Izuo N, Awano T, Takabe K, Shimizu T, Irie K. An RNA aptamer with potent affinity for a toxic dimer of amyloid β42 has potential utility for histochemical studies of Alzheimer's disease. J Biol Chem. 2020 Apr 10;295(15):4870-4880. doi: 10.1074/jbc.RA119.010955.
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