DP7 Aptamer Details

ID# 8845

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Structure

Chemistry

RNA

Target

Human prion protein (PrP)

Sequence (3-char table code)

G A C U/T

5'-rGprGprGprAprGprAprAprAprGprGprGprAprAprGprCprUprUprGprAprGprGprUprGprCprUprAprUprGprGprAprGprUprGprGprAprGprGprAprGprUprUprGprAprAprGprGprUprGprUprCprGprGprGprGprUprUprGprGprCprAprGprAprAprGprAprAprGprGprCprGprAprGprCprGprUprAprCprGprGprAprUprCprCprAprUprCp-3'

Molecular Weight: 28288

Extinction Coefficient: 889500

Binding Conditions / Buffer

Binding buffer (8 M urea, 20 mM sodium phosphate, 500 mM sodium chloride, pH 7.8)

Binding Temp: 37°C

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Mollasalehi N., Francois-Moutal L., Porciani D., Burke D.H., & Khanna M. (2022). Aptamers Targeting Hallmark Proteins of Neurodegeneration. Nucleic Acid Therapeutics, 32(4). https://doi.org/10.1089/nat.2021.0091 Proske D., Gilch S., Wopfner F., Schätzl H.M., Winnacker E-L. Famulok M. (2002). Prion-Protein-Specific Aptamer Reduces PrPSc Formation. Chem BioChem, 3(8), 717-725 https://doi.org/10.1002/1439-7633(20020802)3:8<717::AID-CBIC717>3.0.CO;2-C

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