Daunomycin (10.10v) Aptamer Details
ID# 7558
Structure
Chemistry
DNA
Target
Daunomycin
Category
Small Organic
Affinity (Kd)
272 nM
Length
41
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dApdCpdCpdApdTpdCpdTpdGpdTpdGpdTpdApdApdGpdGpdGpdGpdTpdApdApdGpdGpdGpdGpdTpdGpdGpdGpdGpdGpdTpdGpdGpdGpdTpdApdCpdGpdTpdCpdTp-3'
Molecular Weight: 12873.4
Extinction Coefficient: 405800
Binding Conditions / Buffer
Binding Buffer ((20 mM Trisƒ??HCl [pH 7.4], 140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 1 mM CaCl2, and 0.05% [v/v] Tween 20)
Binding Temp:
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Wochner, et al. "A DNA aptamer with high affinity and specificity for therapeutic anthracyclines." Analytical Biochemistry, 373(2008): 34-42.
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