D1 Aptamer Details

ID# 8214

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Structure

Chemistry

DNA

Target

Human Collagen XIα1 (C-telopeptide region)

Sequence (3-char table code)

G A C U/T

5'-dGpdGpdTpdTpdGpdApdCpdGpdGpdCpdApdGpdTpdCpdGpdGpdCpdGpdGpdTpdApdTpdGpdCpdGpdCpdApdTpdApdTpdCpdGpdTpdGpdTpdTpdGpdGpdTpdAp-3'

Molecular Weight: 12534.09

Extinction Coefficient:

Binding Conditions / Buffer

1x PBS selection buffer With tRNA in a 1:10 ratio with library and 1 ug/mL BSA included to increase stringency

Binding Temp: 37°C

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Lorenzo-Gomez, R, et al. Aptamers targeting a tumor-associated extracellular matrix component: The human mature collagen XIa1. Analytica Chimica Acta, 1189 (2022): 339206. doi: https://doi.org/10.1016/j.aca.2021.339206

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