Cyclophilin B (M9-5) Aptamer Details
ID# 7702
Structure
Chemistry
2'-F-RNA
Target
Cyclophilin B (CypB) pancreatic cell line
Category
Protein
Affinity (Kd)
1.5 nM
Length
71
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-rGprGprGp rAprGprGp rApfCprGp rApfUprGp fCprGprGp rGprGprAp fCpfCpfUp rApfUprGp fCprAprGp fUprAprGp fCpfCprAp rGpfUprGp fUprGprGp rApfCpfUp rGprGprGp fCpfUprGp fCpfCpfCp fCpfCpfCp fCpfCprAp rGprApfCp rGprApfCp fUpfCprGp fCpfCpfCp rGprAp-3'
Molecular Weight: 23031.81
Extinction Coefficient: 674400
Binding Conditions / Buffer
Buffer F: 20 mM HEPES pH 7.5, 150 mM NaCl, 2mM CaCl2, and 3 mM MgCl2
Binding Temp: 37°C
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Ray, P. (2012). Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin b as a candidate pancreatic cancer biomarker. J. Clin. Invest., 122(5), 1734-1741. doi: 10.1172/JC162385
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