CRP-U^gu4 Aptamer Details

ID# 8064

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Structure

Chemistry

DNA

Target

Human C-reactive protein (CRP)

Sequence (3-char table code)

G A C U/T

5'-dCpdtpdApdGpdtpdtpdCpdtpdGpdCpdCpdtpdtpdApdApdtpdApdtpdGpdGpdtpdCpdGpdGpdtpdtpdApdApdGpdCp-3'

Molecular Weight: 9203

Extinction Coefficient: 283200

Binding Conditions / Buffer

40 mM HEPES, pH7.5, 125 mM NaCl, 5 mM KCl, 1 mM MgCl2, 0.01% Tween 20

Binding Temp: 25°C

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Minagawa H, Kataoka Y, Fujita H, Kuwahara M, Horii K, Shiratori I, Waga I. Modified DNA Aptamers for C-Reactive Protein and Lactate Dehydrogenase-5 with Sub-Nanomolar Affinities. International Journal of Molecular Sciences. 2020; 21(8):2683. https://doi.org/10.3390/ijms21082683

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