CoV2-S (T2) Aptamer Details
ID# 10154
Structure
Chemistry
DNA
Target
CoV2-S
Category
Protein
Affinity (Kd)
1.3 nM
Length
31
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dApdGpdGpdCpdGpdCpdGpdTpdGpdTpdApdTpdCpdGpdTpdTpdApdCpdApdCpdApdCpdCpdCpdApdGpdCpdApdGpdCpdCp-3'
Molecular Weight: 9466.2 g/mole
Extinction Coefficient: 292900
Binding Conditions / Buffer
SELEX A: 34.7 mM Na2HPO4*2 H2O; 11.3 mM NaH2PO4*2 H2O; 4 mM KCl, 3 mM urea; 3 mM MgCl2; 1 mg ml−1 BSA; 0.05% Tween‐20; adjusted to pH 7.0
SELEX B: 3.93 mM Na2HPO4*2 H2O; 1.47 mM KH2PO4* H2O; 137 mM NaCl; 2.68 mM KCl; 1 mM MgCl2; 1 mg ml−1 BSA; 0.1% Tween‐20, 0.1 mg ml−1 Salmon sperm DNA, adjusted to pH 7.4
Binding Temp: SELEX A: 25C, SELEX B: 37C°C
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Moradzadeh N, Jonczyk A, Schmitz A, Fieberg V, Civit L, Valero J, Famulok M, Mayer G. Selection and Characterization of SARS-CoV-2 Spike Binding Clickmers. Chembiochem. 2026 Jan;27(1):e202500733. doi: 10.1002/cbic.202500733.
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