Celiac disease Aptamer (Gli1) Aptamer Details

ID# 8791

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Structure

Chemistry

DNA

Target

33-mer peptide (immunodominant fragment from α2-gliadin)

Sequence (3-char table code)

G A C U/T

5'-dCpdTpdApdGpdGpdCpdGpdApdApdApdTpdApdTpdApdGpdCpdTpdApdCpdApdApdCpdTpdGpdTpdCpdTpdGpdApdApdGpdGpdCpdApdCpdCpdCpdApdApdTp-3'

Molecular Weight: 13200

Extinction Coefficient:

Binding Conditions / Buffer

50 mM TRIS-HCl, 0.25 M NaCl, 5mM MgCl2

Binding Temp: 30°C

Refolding Protocol

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Gonzalez S., et. al. "Aptamer Binding to Celiac Disease-Triggering Hydrophobic Proteins A Sensitive Gluten Detection Approach." 2014. Analytical Chemistry 86: 2733-39. González S., Álvarez N., Ordieres O. & Castañón M. (2015). "Sensitive gluten determination in gluten-free foods by an electrochemical aptamer-based assay." Volume 407, pages 6021–6029. https://doi.org/10.1007/s00216-015-8771-6

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