Carcinoembryonic Antigen Aptamer (YJ-1) Aptamer Details
ID# 7712
Structure
Chemistry
Chimeric
Target
Carcinoembryonic Antigen (CEA)
Category
Protein
Affinity (Kd)
0.77 nM
Length
49
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-rGpfCprGprGprAprAprGpfCprGpfUprGpfCpfUprGprGprGpfCpfUprAprGprAprApfUprAprApfUprAprApfUprAprAprGprAprAprAprApfCpfCprAprGpfUprApfCpfUpfUpfUpfCprGpfUp-3'
Molecular Weight: 15869.54
Extinction Coefficient: 507000
Binding Conditions / Buffer
30 mM Tris-HCL, 150 mM NaCK, 1.5 mM MgCl2, 2 mM dithiothreitol, 1% bovine serum albumin, pH 7.5
Binding Temp: RT°C
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
YJ Lee et al. An RNA aptamer that binds carcinoembryonic antigen inhibits hepatic metastasis of colon cancer cells in mice. Gastroenterology 143(2012): 155-165.
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