C-Met Aptamer Aptamer Details
ID# 9110
Structure
Chemistry
DNA
Target
C-Met
Category
Protein
Affinity (Kd)
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Length
40
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
dTpdGpdGpdApdTpdGpdGpdTpdApdGpdCpdTpdCpdGpdGpdTpdCpdGpdGpdGpdGpdTpdGpdGpdGpdTpdGpdGpdGpdTpdTpdGpdGpdCpdApdApdGpdTpdCpdTp
Molecular Weight: 12567.1 g/mole
Extinction Coefficient: 382700
Binding Conditions / Buffer
Binding Temp:
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Chen, K., Cai, J., Wang, S., Li, Y., Yang, C., Fu, T., Zhao, Z., Zhang, X., & Tan, W. (2022). Aptamer inhibits tumor growth by leveraging cellular proteasomal degradation system to degrade c‐met in mice. Angewandte Chemie International Edition, 62(2). https://doi.org/10.1002/anie.202208451 |
Shuxuan Shao, Wei Du, Shuang Liu, Canqiong Hu, Cao Zhang, Lexun Li, Fan Yang, Qiaoling Liu, and Weihong Tan (2024). Reconfigurable Amphiphilic DNA Nanotweezer for Targeted Delivery of Therapeutic Oligonucleotides. ACS Central Science 2024 10 (12), 2338-2345 https://doi.org/10.1021/acscentsci.4c01152
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