Brain Penetrating Aptamer (A15) Aptamer Details

ID# 7840

Back to Search Results

Structure

Chemistry

2'-F-RNA

Target

Brain capillary endothelia and parenchyma

Sequence (3-char table code)

G A C U/T

5'-rGprGprGprAprGprGprApfCprGprApfUprGpfCprGprGpfCprGpfUprApfUpfUprGpfCprGpfCprGprAprGprGprApfUpfUprApfUpfCpfCprGpfCpfUpfCprApfUpfCprGpfUpfUprGpfUpfUprGp fUpfUprGpfUprGpfCprAprGprApfCprGprApfCpfUpfCprGpfCpfCpfCprGprAp -3'

Molecular Weight: 22979.59

Extinction Coefficient: 690300

Binding Conditions / Buffer

SELEX selection buffer: 10 mM HEPES (pH 7.4), 50 mM NaCl, 1 mM MgCl2, 1 mM CaCl2, 0.01% bovine serum albumin. Selection was conducted in situ in mice.

Binding Temp: 37°C

Refolding Protocol

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Cheng C, B Davidson, et al. (2013) In vivo SELEX for identification of brain-penetrating aptamers. Molecular Therapy - Nucleic Acids 2: e67.

Request a Quote Have your aptamer oligo synthesized by Aptagen.