BI1 Aptamer Details

ID# 8220

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Structure

Chemistry

DNA

Target

BACE1

Sequence (3-char table code)

G A C U/T

5'-dApdGpdCpdGpdApdTpdApdCpdTpdGpdCpdGpdTpdGpdGpdCpdTpdGpdGpdApdGpdGpdCpdGpdGpdGpdTpdApdGpdGpdGpdCpdCpdApdGpdApdGpdTpdTpdCp-3'

Molecular Weight: 12578.10

Extinction Coefficient:

Binding Conditions / Buffer

4.5 g glucose, 100 mg tRNA, 50 mg of salmon sperm DNA, 1 g BSA, and 5 mL of 1 M MgCl21 in 1 L of DPBS

Binding Temp: 37°C

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Jun Xiang, Wen Zhang, Xiao-Fang Cai, Min Cai, Zhong-Hai Yu, Feng Yang, Wen Zhu, Xiang-Ting Li, Ting Wu, Jing-Si Zhang, Ding-Fang Cai, DNA Aptamers Targeting BACE1 Reduce Amyloid Levels and Rescue Neuronal Deficiency in Cultured Cells, Molecular Therapy - Nucleic Acids, Volume 16, 2019, Pages 302-312, ISSN 2162-2531.

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