BI-1 Aptamer Details

ID# 9545

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Structure

Chemistry

DNA

Target

BACE2

Sequence (3-char table code)

G A C U/T

5'-dApdTpdCpdCpdApdGpdApdGpdTpdGpdApdCpdGpdCpdApdGpdCpdApdApdGpdCpdGpdApdTpdApdCpdTpdGpdCpdGpdTpdGpdGpdCpdTpdGpdGpdApdGpdGpdCpdGpdGpdGpdTpdApdGpdGpdGpdCpdCpdApdGpdApdGpdTpdTpdCpdTpdGpdGpdApdCpdApdCpdGpdGpdTpdGpdGpdCpdTpdTpdApdGpdTp-3'

Molecular Weight: 23711.3 g/mole

Extinction Coefficient: 739500

Binding Conditions / Buffer

NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Binding Temp:

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Xiang J, Zhang W, Cai XF, Cai M, Yu ZH, Yang F, Zhu W, Li XT, Wu T, Zhang JS, Cai DF. DNA Aptamers Targeting BACE1 Reduce Amyloid Levels and Rescue Neuronal Deficiency in Cultured Cells. Mol Ther Nucleic Acids. 2019 Jun 7;16:302-312. doi: 10.1016/j.omtn.2019.02.025.

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