BG2 Aptamer Details
ID# 9794
Structure
Chemistry
DNA
Target
Alkaline phosphatase (AP) heterodimers
Category
Protein
Affinity (Kd)
37 °C
Length
44
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dCpdApdApdGpdGpdApdApdTpdApdGpdGpdGpdGpdTpdCpdGpdGpdTpdGpdTpdGpdGpdGpdTpdGpdGpdTpdTpdApdTpdGpdApdTpdTpdGpdGpdCpdTpdTpdCpdCpdTpdTpdGp-3'
Molecular Weight:
Extinction Coefficient:
Binding Conditions / Buffer
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Binding Temp: The aptamer successfully binds to many different protein heterodimers therefore the affinity and specificity vary depending on the specific target.
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Bing T, Shen L, Wang J, Wang L, Liu X, Zhang N, Xiao X, Shangguan D. Aptameric Probe Specifically Binding Protein Heterodimer Rather Than Monomers. Adv Sci (Weinh). 2019 Apr 9;6(11):1900143. doi: 10.1002/advs.201900143. PMID: 31179220; PMCID: PMC6548965.
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