ASO15nt(APP) Aptamer Details

ID# 9745

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Structure

Chemistry

DNA

Target

Flanking sequence of APP 3′-UTR D-rG4

Sequence (3-char table code)

G A C U/T

5'-dApdApdGpdApdCpdCpdApdGpdCpdApdGpdApdGpdCpdAp-3'

Molecular Weight: 4604.1 g/mole

Extinction Coefficient: 159800

Binding Conditions / Buffer

25 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 150 mM KCl

Binding Temp: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Zhao, H., Lau, H. L., Zhang, K., & Kwok, C. K. (2024). Selective recognition of RNA G-quadruplex in vitro and in cells by L-aptamer-D-oligonucleotide conjugate. Nucleic acids research, 52(22), 13544–13560. https://doi.org/10.1093/nar/gkae1034 L-RNA Aptamer-Based Tools for G-Quadruplex Structure: Identification, Characterization, and Application Danyang Ji, Kun Zhang, Maryana Yarshova, and Chun Kit Kwok Accounts of Chemical Research 2025 58 (21), 3247-3258 DOI: 10.1021/acs.accounts.5c00468

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