ApTLR#4FT Aptamer Details
ID# 9775
Structure
Chemistry
DNA
Target
Toll-like receptor type 4
Category
Small Organic
Affinity (Kd)
Not provided nM
Length
59
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dGpdGpdTpdGpdTpdGpdCpdCpdApdApdTpdApdApdApdCpdCpdApdTpdApdTpdCpdGpdCpdCpdGpdCpdGpdTpdTpdApdGpdCpdApdTpdGpdTpdApdCpdTpdCpdGpdGpdTpdTpdGpdGpdCpdCpdCpdTpdApdApdApdTpdApdCpdGpdApdGp-3'
Molecular Weight: 18170.8 g/mole
Extinction Coefficient: 568700
Binding Conditions / Buffer
20 mM Tris-HCl [pH 7.4]; 150 mM NaCl; 1 mM MgCl2
Binding Temp: 37 °C
Refolding Protocol
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Gerónimo Fernández, Ana Moraga, María I. Cuartero, Alicia García-Culebras, Carolina Peña-Martínez, Jesús M. Pradillo, Macarena Hernández-Jiménez, Silvia Sacristán, M. Irene Ayuso, Rafael Gonzalo-Gobernado, David Fernández-López, M. Elena Martín, María A. Moro, Victor M. González, Ignacio Lizasoain,TLR4-Binding DNA Aptamers Show a Protective Effect against Acute Stroke in Animal Models, Molecular Therapy, Volume 26,Issue 8,2018,Pages 2047-2059,ISSN 1525-0016
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