Aptamer TY04 Aptamer Details

ID# 7938

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Structure

Chemistry

DNA

Target

Multiple myeloma cells (MM.1S)

Sequence (3-char table code)

G A C U/T

5'-dApdTpdCpdGpdTpdCpdTpdGpdCpdTpdCpdCpdGpdTpdCpdCpdApdApdTpdApdTpdApdTpdCpdApdApdApdGpdGpdCpdGpdApdApdTpdTpdTpdTpdGpdTpdCpdApdApdGpdGpdTpdGpdTpdTpdApdApdApdCpdGpdApdTpdApdGpdTpdCpdCpdCpdTpdApdCpdCpdTpdTpdTpdGpdGpdTpdGpdTpdGpdApdGpdGpdTpdCpdGpdTpdGpdCp-3'

Molecular Weight: 25587.67

Extinction Coefficient: 794400

Binding Conditions / Buffer

yeast tRNA (0.1mg/ml; Sigma) and BSA (1 mg/ml; Sigma) into the wash buffer

Binding Temp: 37°C

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Dai, H. et al. "Aptamer TY04 inhibits the growth of multiple myeloma cells via cell cycle arrest." Tumor Biology 2014: 1-8.

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