Aptamer CIV6 against Acyclic Guanosine Analogues Aptamer Details
ID# 9411
Structure
Chemistry
DNA
Target
Acyclic Guanosine Analogues: acyclovir (ACV), famciclovir (FCV), ganciclovir (GCV), penciclovir (PCV), and valaciclovir (VACV)
Category
Small Organic
Affinity (Kd)
32.67±4.127 (ACV), 47.91±13.47 (GCV), 33.29±5.851 (PCV), 47.35±10.42 (FCV), 44.26±6.744 (VACV) nM
Length
80
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dTpdGpdApdGpdCpdCpdCpdApdApdGpdCpdCpdCpdTpdGpdGpdTpdApdTpdGpdTpdGpdApdApdApdApdCpdApdTpdApdCpdTpdApdGpdApdCpdGpdTpdGpdGpdCpdTpdApdTpdGpdTpdApdTpdTpdTpdTpdTpdApdApdApdTpdCpdApdApdTpdGpdGpdCpdApdGpdGpdTpdCpdTpdApdCpdTpdTpdTpdGpdGpdGpdApdTpdCp-3'
Molecular Weight: 24722 g/mole
Extinction Coefficient: 778400
Binding Conditions / Buffer
1mL BB, (50 mMTris-HCl, 5 mM KCl, 100 mM NaCl, 1 mM MgCl2, pH 7.4)
Binding Temp: 37 °C °C
Refolding Protocol
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Ren, L., Qi, S., Khan, I. M., Wu, S., Duan, N., & Wang, Z. (2021). Screening and application of a broad-spectrum aptamer for acyclic guanosine analogues. Analytical and bioanalytical chemistry, 413(19), 4855–4863. https://doi.org/10.1007/s00216-021-03446-w
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