Apt A1 Aptamer Details
ID# 8000
Structure
Chemistry
DNA
Target
BACE1
Category
Protein
Affinity (Kd)
68.6 nM
Length
73
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5’-dGpdCpdAp dApdTpdGp dGpdTpdAp dCpdGpdGp dTpdApdCp dTpdTpdCp dCpdGpdTp dCpdApdTp dCpdApdGp dCpdTpdTp dGpdTpdGp dApdTpdGp dTpdGpdGp dApdTpdGp dCpdGpdAp dApdCpdTp dGpdCpdAp dApdApdAp dGpdTpdGp dCpdApdCp dGpdCpdTp dApdCpdTp dTpdTpdGp dCpdTpdAp dAp-3’
Molecular Weight: 22542
Extinction Coefficient: 698200
Binding Conditions / Buffer
Selection Buffer: 5 M guanidine-HCl in 50 mM Tris
Binding Temp: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Zhi-Man Liang, et al. “The BACE1-Specific DNA Aptamer A1 Rescues Amyloid-b Pathology and Behavioral Deficits in a Mouse Model of Alzheimer’s Disease”. 00. 00. 2019.
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