Apt-11 inhibiting α-Synuclein Seeding-Dependent Aggregation Aptamer Details

ID# 9419

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Structure

Chemistry

DNA

Target

α-syn monomers mixed with α-syn 122 seeds

Sequence (3-char table code)

G A C U/T

5'-dApdGpdTpdGpdCpdApdApdGpdCpdApdGpdTpdApdTpdTpdCpdGpdGpdTpdCpdCpdTpdGpdApdCpdApdCpdTpdCpdGpdGpdCpdTpdTpdTpdTpdTpdApdTpdCpdTpdTpdCpdCpdCpdTpdGpdCpdTpdTpdCpdGpdGpdTpdCpdCpdTpdGpdTpdCpdTpdApdApdApdGpdCpdTpdGpdApdTpdGpdCpdGpdTpdGpdApdTpdGpdCpdCp-3'

Molecular Weight: 12097.8 g/mole

Extinction Coefficient: 339900

Binding Conditions / Buffer

NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Binding Temp: Specific to C-Terminally Truncated α-Synuclein Fibrils

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Hmila, Issam and Sudhakaran, Indulekha P. and Ghanem, Simona S. and Vaikath, Nishant N. and Poggiolini, Ilaria and Abdesselem, Houari and El-Agnaf, Omar M. A. Inhibition of α-Synuclein Seeding-Dependent Aggregation by ssDNA Aptamers Specific to C-Terminally Truncated α-Synuclein Fibrils. ACS Chemical Neuroscience. 2022. https://doi.org/10.1021/acschemneuro.2c00362

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