Apt-07S Aptamer Details
ID# 8108
Structure
Chemistry
DNA
Target
HepG2 (Kd = 194.7nM) and SMMC-7721 (Kd = 224.2nM)
Category
Cells
Affinity (Kd)
194.7 and 224.2 nM
Length
47
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dGpdTpdApdCpdTpdGpdTpdCpdApdApdTpdTpdGpdGpdApdApdGpdTpdGpdGpdTpdGpdTpdTpdApdCpdGpdTpdTpdGpdTpdGpdTpdApdGpdTpdCpdApdApdApdTpdCpdApdGpdTpdGpdCp-3'
Molecular Weight: 14594.5
Extinction Coefficient: 462500
Binding Conditions / Buffer
1×PBS–1 mM MgCl2–0.1 μg/μL ytRNA–0.1 μg/μL wDNA–X pmol ssDNA library.
Binding Temp: 4°C
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Yu XX, Ge KL, Liu N, Zhang JY, Xue ML, Ge YL. Selection and Characterization of a Novel DNA Aptamer, Apt-07S Specific to Hepatocellular Carcinoma Cells. Drug Des Devel Ther. 2020 Apr 20;14:1535-1545. doi: 10.2147/DDDT.S244149. PMID: 32368012; PMCID: PMC7182459.
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