AP-1 Aptamer Details
ID# 8111
Structure
Chemistry
DNA
Target
Proprotein Convertase Subtilisin/Kexin 9
Category
Protein
Affinity (Kd)
294 nM
Length
88
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5’-dApdTpdApdCpdCpdApdGpdCpdTpdTpdApdTpdTpdCpdApdApdTpdTpdGpdApdCpdCpdCpdGpdTpdTpdTpdCpdGpdTpdTpdCpdCpdCpdTpdCpdTpdGpdGpdGpdApdApdGpdTpdTpdTpdApdGpdCpdCpdCpdApdGpdTpdTpdGpdCpdCpdTpdGpdGpdGpdCpdGpdApdTpdApdCpdCpdApdApdGpdApdTpdApdGpdTpdApdApdGpdTpdGpdCpdApdApdTpdCpdTp-3’
Molecular Weight: 27041.5
Extinction Coefficient: 835800
Binding Conditions / Buffer
25 mM Tris-HCl, 192 mM glycine, 5 mM KH2PO4, and pH 8.3
Binding Temp: 37°C
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Sattari R, Palizban A, Khanahmad H. Single-Strand DNA-Like Oligonucleotide Aptamer Against Proprotein Convertase Subtilisin/Kexin 9 Using CE-SELEX: PCSK9 Targeting Selection. Cardiovasc Drugs Ther. 2020 Aug;34(4):475-485. doi: 10.1007/s10557-020-06986-y. PMID: 32415571.
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