Anti-VEGF165 Unnatural Base DNA Aptamer #4 Aptamer Details
ID# 7985
Structure
Chemistry
Chimeric
Target
VEGF165
Category
Protein
Affinity (Kd)
0.9 pM
Length
56
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dGpdCpdGpdGpdTpdApdApdApdCpdTpdGpdCpdGpdTpdCpdCpdGpdApdApdGpdGpdGpdGpdCpdTpdGpdCpdApdGpdTpdGpdApdCpdCpdCpdGpdApdApdTpdGpdGpdGpdTpdCpdCpdGpdCpdCpdGpdCpdGpdApdApdGpdCpdGp-3'
Molecular Weight:
Extinction Coefficient:
Binding Conditions / Buffer
1?? PBS (1 mM KH2PO4, 3 mM Na2HPO4 and 155 mM NaCl, pH 7.4, Gibco)
Binding Temp: 37°C
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Kimoto M., Nakamura M., Hirao I. July 7 2016. Post-ExSELEX stabilization of an unnatural-base DNA aptamer targeting VEGF165 toward pharmaceutical applications. Nucleic Acids Research 44(15): 7487-7494.
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