Anti-IgE Aptamer, D 17.4 ext Aptamer Details
ID# 7666
Structure
Chemistry
DNA
Target
IgE (human)
Category
Protein
Affinity (Kd)
3.6 nM
Length
45
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dGpdCpdGpdCpdGpdGpdGpdGpdCpdApdCpdGpdTpdTpdTpdApdTpdCpdCpdGpdTpdCpdCpdCpdTpdCpdCpdTpdApdGpdTpdGpdGpdCpdGpdTpdGpdCpdCpdCpdCpdGpdCpdGpdCp-3'
Molecular Weight: 13758.86
Extinction Coefficient: 394100
Binding Conditions / Buffer
PBS containing 1 mM MgCl2 (pH 7.4)
Binding Temp:
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Aptamer Selection Reference: Wiegand, T.W., et al. "High-Affinity Oligonucleotide Ligands to Human IgE Inhibit Binding to FCE Receptor I." Journal of Immunology, 157 (1996): 221-230
Liss, M., et al. "An Aptamer-Based Quartz Crystal Protein Biosensor." Anal. Chem.,74 (2002): 4488-4495.
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