Anti-EGFR (E03) Aptamer Details

ID# 7723

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Structure

Chemistry

2'-F-RNA

Target

mEGFR and hEGFR

Sequence (3-char table code)

G A C U/T

5'- rGprGpfCprGpfCpfUpfCpfCprGprAp fCpfCpfUpfUprAprGpfUpfCpfUpfCp fUprGpfUprGpfCpfUprAprGpfUprAp fUprApfUpfCprGpfCprApfCprGprGp rApfUpfUpfUprAprApfUpfCprGpfCpfCprGpfUprAprGprAprAprAprAprGp fCprApfUprGpfUpfCprAprAprAprGp fCpfCprGprGprAprApfCpfCprGpfUp rGpfUprAprGpfCprApfCprAprGpfCp rAprGprAp-3'

Molecular Weight: 29988.85

Extinction Coefficient: 921300

Binding Conditions / Buffer

1X DPBS, 5mM MgCl2, pH 7.1-7.5

Binding Temp: 25°C

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

N. Li et al. "Inhibition of Cell Proliferation by an Anti-EGFR Aptamer." PLoS One 6(2011): e20299.

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