Anti-acetylcholine Autoantibodies (SE RNA) Aptamer Details
ID# 7538
Structure
Chemistry
DNA
Target
Anti-acetylcholine Autoantibodies
Category
Protein
Affinity (Kd)
60 nM
Length
48
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-nUprGprGprGpnCpnCprGprGprAprGprGpnUpnUprAprGpnCpnUpnUprGpnCpnCpnCprApnUprGprGpnCprAprAprGpnCprAprGprGprGpnCprGpnCpnCprApnCprGprGprApnCpnCpnCprAp-3'
Molecular Weight: 28339.52
Extinction Coefficient: 455500
Binding Conditions / Buffer
Binding Buffer (30 mM Tris-HCl (pH 7.5), 150 mM NaCl, 10 mM MgCl2, 2 mM DTT, 1% BSA)
Binding Temp:
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Lee and Sullenger. "Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies." Nature Biotechnology, 15(1997):
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