Anti -?1-Adrenergic Receptor-Autoantibodies (Aptamer 110) Aptamer Details
ID# 7665
Structure
Chemistry
DNA
Target
?1-Adrenoceptor Autoantibodies(AABs)
Category
Protein
Affinity (Kd)
n/a nM
Length
21
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dApdCpdApdGpdTpdApdApdCpdCpdGpdCpdGpdTpdGpdApdGpdGpdTpdCpdGpdAp-3'
Molecular Weight: 6480.27
Extinction Coefficient: 212600
Binding Conditions / Buffer
Buffer 1: Tris buffer pH 7.3, 0.1% Tween-20, DMEM, 0.1% Tween-20 Buffer 2: Phosphate buffer pH 7.5, 0.1% Tween-20
Binding Temp:
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Haberland, A., et al. "Aptamer Neutralization of Beta1-Adrenoceptor Autoantibodies Isolated From Patients With Cardiomyopathies." Circulation Research, 109 (2011): 986-992.
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