AMPA GluR2 (AN58) Aptamer Details

ID# 7809

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Structure

Chemistry

RNA

Target

AMPA GluR2 Glutamate Receptor Channel

Sequence (3-char table code)

G A C U/T

5'-rGprGprGprCprGprAprAprUprUprCprAprAprCprUprGprCprCprAprUprCprUprAprGprGprCprAprGprUprAprAprCprCprAprGprGprAprGprUprUprAprGprUprAprGprGprAprCprAprAprGprUprUprUprCprGprUprCprCp-3'

Molecular Weight: 18676.31

Extinction Coefficient: 584600

Binding Conditions / Buffer

10% DMSO in Extracellular Buffer: 150 mM NaCl, 3 mM KCl, 1 mM CaCl2, 1 MgCl2, 10 HEPEs (pH 7.4) Incubation Time: 40 min

Binding Temp: 22°C

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Z. Huang et al. RNA aptamers selected against the GluR2 glutamate receptor channel. Biochemistry 46(2007): 12648 - 12655. Z. Huang et al. One RNA aptamer sequence, two structures: a collaborating pair that inhibits AMPA receptors. Nucleic Acids Res.. 37(2009): 4022 - 4032

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