Advanced Glycation End Products (Clone 9) Aptamer Details

ID# 7533

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Structure

Chemistry

DNA

Target

Advanced Glycation End products (AGE)

Sequence (3-char table code)

G A C U/T

5'-dApdGpdCpdTpdCpdApdGpdApdApdTpdGpdGpdApdTpdCpdCpdApdApdApdCpdGpdCpdTpdCpdApdTpdApdApdCpdTpdCpdApdCpdTpdCpdCpdApdTpdApdCpdTpdCpdApdCpdTpdTpdGpdCpdTpdGpdApdTpdTpdCpdGpdCpdCpdApdApdCpdApdApdCpdApdCpdApdCpdCpdCpdTpdTpdApdApdApdCpdApdGpdTpdCpdCpdCpdTpdTpdCpdGpdApdCpdApdTpdGpdApdGpdApdApdTpdTpdCpdGpdGpdCpdCpdGpdGpdApdTpdCp-3'

Molecular Weight: 32346.02

Extinction Coefficient: 1004700

Binding Conditions / Buffer

Binding Temp:

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Higashimoto, Y., et al. "In vitro selection of DNA aptamers that block toxic effects of AGE on cultured retinal pericytes." Microvascular Research, 74 (2007): 65-69.

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