Acetylcholine Receptor Antibody (mAB198) (SE RNA VII) Aptamer Details
ID# 7482
Structure
Chemistry
DNA
Target
Acetylcholine Receptor Antibody (mAB198)
Category
Protein
Affinity (Kd)
60 nM
Length
48
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-nUprGprGprGpnCpnCprGprGprAprGprGpnUpnUprAprGpnCpnUpnUprGpnCpnCpnCprApnUprGprGpnCprAprAprGpnCprAprGprGprGpnCprGpnCpnCprApnCprGprGprApnCpnCpnCprAp-3'
Molecular Weight: 28339.52
Extinction Coefficient: 455500
Binding Conditions / Buffer
Binding Buffer (30mM Tris-HCl (pH 7.5), 150 mM NaCl, 10mM MgCl2, 2mM dithiothreitol, 1% BSA)
Binding Temp:
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Lee, Seong-Wook and Sullenger, Bruce. "Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies." Nature Biotechnology, 15 (1997): 41-45.
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