A14 Aptamer Details
ID# 7921
Structure
Chemistry
RNA
Target
Penetrating the Blood Brain Barrier (BBB)
Category
Other
Affinity (Kd)
10mM HEPES, pH 7.4, 50mM NaCl, 1mM MgCl2, 1mM CaCl2, 0.01% BSA
Length
55
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
rGprGprGprAprGprGprAprCprGprApUrGprCprGprGprGpUrAprGprCprCpUUUrCprGprGpUrGprGpUrCprCprGpUUrApUrCpUrCprCprAprCprApUrCprAprCprGpUrCpUrGprCprAprGprAprCprGprAprCpUrCprGprCprCprCprGprAp
Molecular Weight: 17891.96
Extinction Coefficient: 521500
Binding Conditions / Buffer
37°C
Binding Temp: Denature at 94C for 3 minutes, and then slowly refold at room temperature
Refolding Protocol
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Congsheng Cheng, Yong Hong Chen, Kim A Lennox, Mark A Behlke, Beverly L Davidson, "In vivo SELEX for Identification of Brain-penetrating Aptamers" Molecular Therapy-Nucleic Acids (2013)2, e67, American Society of Gene & Cell Therapy
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