A1 Aptamer Details
ID# 9535
Structure
Chemistry
DNA
Target
BACE1
Category
Small Organic
Affinity (Kd)
68.5655 ± 8.1237 nM
Length
73
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dGpdCpdApdApdTpdGpdGpdTpdApdCpdGpdGpdTpdApdCpdTpdTpdCpdCpdGpdTpdCpdApdTpdCpdApdGpdCpdTpdTpdGpdTpdGpdApdTpdGpdTpdGpdGpdApdTpdGpdCpdGpdApdApdCpdTpdGpdCpdApdApdApdApdGpdTpdGpdCpdApdCpdGpdCpdTpdApdCpdTpdTpdTpdGpdCpdTpdApdAp-3'
Molecular Weight: 22541.6 g/mole
Extinction Coefficient: 698200
Binding Conditions / Buffer
RT°C
Binding Temp: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Liang H, Shi Y, Kou Z, Peng Y, Chen W, Li X, Li S, Wang Y, Wang F, Zhang X. Inhibition of BACE1 Activity by a DNA Aptamer in an Alzheimer's Disease Cell Model. PLoS One. 2015 Oct 16;10(10):e0140733. doi: 10.1371/journal.pone.0140733. PMID: 26473367; PMCID: PMC4608735.
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