#97 Aptamer Details

ID# 8849

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Structure

Chemistry

DNA

Target

Hamster prion protein (Sequence 90-231)

Sequence (3-char table code)

G A C U/T

5'-dTsdGsdCsdTsdGsdCsdGsdGsdTsdTsdCsdGsdAsdCsdAsdCsdAsdAsdGsdCsdCsdGsdAsdGsdCsdGsdTsdTsdTsdAsdGsdGsdCsdTsdAsdCsdGsdGsdTsdAs-3'

Molecular Weight: 12353

Extinction Coefficient: 380500

Binding Conditions / Buffer

1X Selection buffer (SB)

Binding Temp: Heated to 100°C for 5 min in 1XSB; Cooled to RT

Refolding Protocol

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Mollasalehi N., Francois-Moutal L., Porciani D., Burke D.H., & Khanna M. (2022). Aptamers Targeting Hallmark Proteins of Neurodegeneration. Nucleic Acid Therapeutics, 32(4). https://doi.org/10.1089/nat.2021.0091 Kind D.J., Safar J.G., Legname G., & Prusiner S.B. (2007). Thioaptamer Interactions with Prion Proteins: Sequence-specific and Non-specific Binding Sites. Journal of Molecular Biology, 369(4), 1001-1014. https://doi.org/10.1016/j.jmb.2007.02.004

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