8-OHdG (22) Aptamer Details
ID# 7687
Structure
Chemistry
DNA
Target
8-OHdG
Category
Other
Affinity (Kd)
0.1 nM
Length
121
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dTpdApdApdTpdApdCpdGpdApdCpdTpdCpdApdCpdGpdTpdApdTpdApdGpdGpdGpdApdApdTpdTpdCpdGpdTpdCpdGpdApdCpdGpdGpdApdTpdGpdCpdGpdGpdGpdCpdGpdApdTpdCpdGpdGpdCpdGpdGpdGpdGpdGpdGpdTpdGpdCpdGpdTpdGpdCpdGpdCpdTpdCpdTpdGpdTpdGpdCpdCpdApdGpdGpdGpdGpdGpdTpdGpdGpdGpdApdCpdApdGpdApdTpdCpdApdTpdApdTpdGpdGpdGpdGpdGpdTpdGpdCpdTpdCpdApdGpdGpdTpdCpdGpdApdCpdGpdCpdApdTpdGpdCpdGpdCpdCpdGp-3'
Molecular Weight: 37780.41
Extinction Coefficient: 1161100
Binding Conditions / Buffer
50 mM Trisƒ??HCl (pH 7.6), 300 mM NaCl, 30 mM KCl, and 5 mM MgCl2
Binding Temp:
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Miyachi, Y. (2009). Selection of a dna aptmaer that binds 8-ohdg using gmp-agarose. Bioorganic & Medicinal Chemistry Letters, 19(2009), 3619-3622.
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