#71T Aptamer Details
ID# 9537
Structure
Chemistry
DNA
Target
BACE1
Category
Small Organic
Affinity (Kd)
10.3±3.7 nM
Length
89
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dGpdCpdCpdTpdGpdTpdTpdGpdTpdGpdApdGpdCpdCpdTpdCpdCpdTpdApdApdCpdGpdGpdCpdGpdTpdApdGpdGpdGpdTpdTpdTpdGpdTpdTpdGpdTpdCpdTpdCpdTpdApdTpdTpdTpdCpdTpdTpdTpdGpdTpdApdTpdTpdGpdTpdGpdTpdTpdGpdTpdGpdTpdTpdCpdGpdCpdTpdTpdApdTpdTpdCpdTpdTpdGpdTpdCpdTpdCpdCpdCp-3'
Molecular Weight: 27308.6 g/mole
Extinction Coefficient: 792200
Binding Conditions / Buffer
78.8°C
Binding Temp: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Gasse C, M Zaarour, S Noppen, M Abramov, P Marlie`re, S Liekens, B De Strooper and P Herdewijn. (2018). Modulation of BACE1 activity by chemically modified aptamers. ChemBioChem 19:754–763. DOI: 10.1002/cbic.201700461
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