71 Aptamer Details
ID# 9591
Structure
Chemistry
DNA
Target
BACE1
Category
Protein
Affinity (Kd)
12.0±1.2 nM
Length
89
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dGpdCpdCpdTpdGpdTpdTpdGpdTpdGpdApdGpdCpdCpdTpdCpdCpdTpdApdApdCpdGpdGpdCpdGpdTpdApdGpdGpdGpdTpdTpdTpdGpdTpdTpdGpdTpdCpdTpdCpdTpdApdTpdTpdTpdCpdTpdTpdTpdGpdTpdApdTpdTpdGpdTpdGpdTpdTpdGpdTpdGpdTpdTpdCpdGpdCpdTpdCpdApdTpdGpdCpdTpdTpdApdTpdTpdCpdTpdTpdGpdTpdCpdTpdCpdCpdCp-3'
Molecular Weight: 27308.6 g/mole
Extinction Coefficient: 792200
Binding Conditions / Buffer
1 mL of selection buffer (137 mM NaCl, 2.7 mM KCl, 6. 5 mM Na₂HPO₄, 1.8 mM NaH₂PO₄,, 1.5 mM MgCl₂, and 0.1% (w/v) BSA, pH 7.4)
Binding Temp: 25°C
Refolding Protocol
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Gasse C, M Zaarour, S Noppen, M Abramov, P Marlie`re, S Liekens, B De Strooper and P Herdewijn. (2018). Modulation of BACE1 activity by chemically modified aptamers. ChemBioChem 19:754–763. DOI: 10.1002/cbic.201700461
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