4C6 Aptamer Details

ID# 8854

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Structure

Chemistry

DNA

Target

Human prion protein (90–231)

Sequence (3-char table code)

G A C U/T

5'-dGpdGpdTpdApdTpdTpdGpdApdGpdGpdGpdTpdCpdGpdCpdApdTpdCpdGpdTpdTpdTpdTpdGpdTpdTpdApdCpdApdGpdTpdTpdCpdGpdTpdTpdTpdCpdTpdTpdTpdTpdCpdCpdCpdTpdGpdTpdCpdTpdTpdGpdTpdTpdTpdTpdGpdTpdTpdGpdTpdCpdTpdGpdApdTpdGpdGpdCpdTpdCpdTpdApdApdCpdTpdCpdTpdCpdCpdTpdCpdTp

Molecular Weight: 25438.4

Extinction Coefficient: 739100

Binding Conditions / Buffer

Selection buffer (50 mM NaH2PO4, 150 mM NaCl, 5 mM KCl, 1 mM MgCl2, 0.005% (v/v) Tween-20, pH 8.0)

Binding Temp: 23°C

Refolding Protocol

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Bibby DF, Gill AC, Kirby L, Farquhar CF, Bruce ME, and Garson JA. (2008). Application of a novel in vitro selection technique to isolate and characterise high affinity DNA aptamers binding mammalian prion proteins. Journal of Virological Methods, (151)1, 107-115. https://doi.org/10.1016/j.jviromet.2008.03.013

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